Follistatin 344
Follistatin 344
An endogenous myostatin and activin inhibitor studied for muscle hypertrophy. One of the most potent anabolic peptides in animal research — with a risk profile to match.
Follistatin 344 is not approved by the FDA for human use. It is sold strictly for research purposes only and is not intended for human consumption, diagnosis, treatment, or prevention of any disease or condition. Purchase and use is entirely at your own risk.
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View at Ascension Peptides →What it is
Follistatin is a naturally occurring glycoprotein that acts as an endogenous inhibitor of myostatin and activin — two proteins that suppress muscle growth. Follistatin-344 refers to the 344-amino acid isoform, which is the most widely studied form in anabolic research.
By blocking myostatin and activin, follistatin removes a primary brake on muscle hypertrophy. Animal models — most famously "double-muscled" cattle with natural myostatin mutations — demonstrate how dramatic the effect of removing this brake can be. Human research is extremely limited.
What research shows
- Dramatic muscle hypertrophy in myostatin-null animal models
- Gene therapy using follistatin in primates produced significant muscle mass increases
- Inhibition of both myostatin and activin — dual pathway suppression
- Some early human gene therapy data in muscular dystrophy patients
- Fat loss signals in some animal models alongside muscle gain
What remains unknown
- Safety profile in healthy humans — essentially no human peptide injection data
- Long-term effects of chronic myostatin suppression on muscle architecture and tendon integrity
- Cancer risk — activin inhibition has complex implications for tumor biology
- Dose-response relationship in humans
Administration basics
Common use cases
Extreme muscle hypertrophy research. Carries substantial unknown risk profile.
Half-life
Not well characterized for injected peptide form.
Administration
Intramuscular injection. Requires significant caution given limited safety data.
Source this compound
Looking for Follistatin 344?
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View at Ascension PeptidesResearch Protocols & Common Usage
Doses used in research
- Gene therapy research has used 100mcg in limited studies
- Community injection protocols commonly report 50–100mcg per injection
Administration routes studied
Typical protocol duration
Very short cycles of 1–2 weeks are commonly reported due to concerns about prolonged myostatin suppression.
Common stacking protocols
- Follistatin-344 + IGF-1 LR3 or MGF — combined in community muscle-building protocols
Contraindications & combinations to avoid
- Cardiac muscle concerns — myostatin regulates cardiac muscle; long-term suppression has unknown consequences for heart function
- Active cancer — follistatin promotes cell growth pathways
- Should not be combined with anabolic steroids or SARMs without careful consideration
- This compound has among the least human safety data of any entry on this platform
Dosing information reflects doses used in published research and commonly reported community protocols only. This is not a personal recommendation. These compounds are not FDA-approved for human use in the contexts described. Consult a qualified healthcare provider before starting any protocol.
Considering stacking?
See the stacking guide for common combinations with Follistatin 344 and what to avoid.
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Reviews reflect individual user experiences with research compounds and are not medical advice. Results vary. These compounds are not FDA approved for human use. Peptelligent does not verify reported experiences.
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