TB-500
Thymosin Beta-4 Fragment (LKKTETQ)
A synthetic analogue of the active region of Thymosin Beta-4, a naturally occurring peptide involved in cell migration and repair.
TB-500 is not approved by the FDA for human use. It is sold strictly for research purposes only and is not intended for human consumption, diagnosis, treatment, or prevention of any disease or condition. Purchase and use is entirely at your own risk.
Sourcing for research purposes?
View at Ascension Peptides →What it is
TB-500 is a synthetic peptide corresponding to the active region of Thymosin Beta-4 (Tβ4), specifically the sequence LKKTETQ. Thymosin Beta-4 is a naturally occurring protein found in high concentrations in blood platelets and wound fluid.
The TB-500 fragment is studied because it appears to retain many of the biological activities of the full Tβ4 protein while being more practical for research use.
What research shows
- Promotes healing of wounds, muscle, skin, heart tissue, and eyes in animal models
- Upregulates actin, a key component of cell migration and tissue structure
- Anti-inflammatory properties in several tissue types
- May improve cardiac function post-injury in animal models
- Synergistic tissue repair when combined with BPC-157
What remains unknown
- Dose-response relationship in humans
- Long-term safety profile in humans
- Whether benefits observed in rodents replicate in human physiology
- Exact mechanism of action for each tissue type studied
Administration basics
Common use cases
Athletic recovery, injury healing. Often stacked with BPC-157 for compounding repair effects.
Half-life
Not well characterized in humans. Animal data suggests several hours to days depending on route.
Administration
Subcutaneous or intramuscular injection.
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View at Ascension PeptidesResearch Protocols & Common Usage
Doses used in research
- Animal studies have used 2–2.5mg per injection
- Community loading protocols commonly report 5–10mg/week for 4–6 weeks
- Community maintenance protocols commonly report 2–2.5mg/week thereafter
Administration routes studied
Typical protocol duration
Community protocols commonly report a loading phase of 4–6 weeks followed by a maintenance phase. Total cycles of 8–12 weeks are frequently reported.
Common stacking protocols
- BPC-157 + TB-500 (The Wolverine Stack) — the most widely reported recovery stack; BPC-157 handles localized repair while TB-500 provides systemic healing
- BPC-157 + TB-500 + GHK-Cu (The GLOW Stack) — adds collagen synthesis and skin remodeling to the recovery foundation
- BPC-157 + TB-500 + GHK-Cu + KPV (The KLOW Stack) — the GLOW Stack with KPV for added anti-inflammatory coverage
- TB-500 + Ipamorelin/CJC-1295 — combined with GH peptides in some athletic recovery protocols
Contraindications & combinations to avoid
- Active cancer or history of cancer — TB-500 promotes cell migration, which could theoretically support tumor spread
- Anticoagulant medications — consult a physician before combining
- Pregnancy and breastfeeding — no safety data available
Dosing information reflects doses used in published research and commonly reported community protocols only. This is not a personal recommendation. These compounds are not FDA-approved for human use in the contexts described. Consult a qualified healthcare provider before starting any protocol.
Considering stacking?
See the stacking guide for common combinations with TB-500 and what to avoid.
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Community Reviews
Reviews reflect individual user experiences with research compounds and are not medical advice. Results vary. These compounds are not FDA approved for human use. Peptelligent does not verify reported experiences.
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