Epithalon
Epithalon (Epitalon) — Ala-Glu-Asp-Gly
A synthetic tetrapeptide derived from the pineal gland's epithalamin, with research on telomerase activation, telomere extension, and longevity.
Epithalon is not approved by the FDA for human use. It is sold strictly for research purposes only and is not intended for human consumption, diagnosis, treatment, or prevention of any disease or condition. Purchase and use is entirely at your own risk.
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View at Ascension Peptides →What it is
Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from epithalamin, a natural substance produced by the pineal gland. It was developed by Vladimir Khavinson and colleagues at the St. Petersburg Institute of Bioregulation and Gerontology, where it has been studied since the 1980s.
The primary research interest centers on its ability to activate telomerase — the enzyme that extends telomeres — in human somatic cells. Telomere shortening is associated with cellular aging, making telomerase activation a significant area of longevity research.
What research shows
- Activation of telomerase and telomere elongation in human fetal cell cultures
- Extended lifespan in animal models (fruit flies and mice)
- Melatonin regulation — pineal gland support and circadian rhythm normalization
- Some human data from Russian longitudinal studies showing reduced mortality in elderly populations
- Antioxidant effects and normalization of neuroendocrine function
What remains unknown
- Western clinical trial validation — most research is Russian and not independently replicated
- Optimal dosing and cycling protocols
- Long-term safety with chronic use
- Whether telomerase activation from epithalon translates to meaningful longevity benefit in already-healthy adults
Administration basics
Common use cases
Longevity protocols, anti-aging, sleep and circadian rhythm support.
Half-life
Very short — typically administered in cycles.
Administration
Subcutaneous injection or intranasal. Typically run in 10-day cycles.
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View at Ascension PeptidesResearch Protocols & Common Usage
Doses used in research
- Khavinson research has used 5–10mg per injection
- Community protocols commonly report 5–10mg/day for a defined course
Administration routes studied
Typical protocol duration
Research and community protocols commonly use 10–20 day courses, repeated 1–2 times per year.
Common stacking protocols
- Epithalon + Pinealon — commonly combined in Russian peptide bioregulator longevity protocols
- Epithalon + Thymalin — combined for immune and longevity support
- Epithalon + GHK-Cu — combined in some anti-aging protocols
Contraindications & combinations to avoid
- Hormone-sensitive conditions — Epithalon influences the pineal gland and melatonin production
- Active cancer — telomerase activation theoretically could affect cancer cell biology; consult an oncologist
- Pregnancy and breastfeeding — no safety data available
Dosing information reflects doses used in published research and commonly reported community protocols only. This is not a personal recommendation. These compounds are not FDA-approved for human use in the contexts described. Consult a qualified healthcare provider before starting any protocol.
Considering stacking?
See the stacking guide for common combinations with Epithalon and what to avoid.
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Reviews reflect individual user experiences with research compounds and are not medical advice. Results vary. These compounds are not FDA approved for human use. Peptelligent does not verify reported experiences.
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