Libido

Kisspeptin

Kisspeptin (Metastin)

A neuropeptide that acts as the master regulator of the reproductive hormone axis (GnRH/LH/FSH). Research in hypogonadism, fertility, and sexual behavior.

Kisspeptin is not approved by the FDA for human use. It is sold strictly for research purposes only and is not intended for human consumption, diagnosis, treatment, or prevention of any disease or condition. Purchase and use is entirely at your own risk.

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What it is

Kisspeptin is a neuropeptide encoded by the KISS1 gene that acts on the kisspeptin receptor (GPR54) in hypothalamic neurons to stimulate GnRH (gonadotropin-releasing hormone) release. This makes it the upstream master regulator of the entire reproductive hormone axis — GnRH → LH/FSH → testosterone/estrogen.

In both men and women, kisspeptin dysfunction has been identified as a cause of hypothalamic hypogonadism. Research has expanded into fertility treatment, sexual behavior, and hormone optimization.

What research shows

Potent stimulation of LH and FSH release in human studies
Restoration of LH pulsatility in hypothalamic hypogonadism
Improved sexual desire and brain activation in response to sexual stimuli in male trials
Fertility research — triggering ovulation in IVF protocols
Potential role in male hypogonadism without suppressing endogenous testosterone production (unlike exogenous testosterone)

What remains unknown

Optimal dosing and pulsing protocols for hormone optimization in healthy individuals
Long-term safety profile with chronic use
Clinical utility versus established treatments like clomiphene or TRT for hypogonadism

Administration basics

Common use cases

Hormone axis support, hypogonadism, fertility, libido. Potentially relevant as an alternative to TRT that preserves endogenous production.

Half-life

~28 minutes (Kisspeptin-10). Longer forms exist with extended half-life.

Administration

Subcutaneous injection. Dosing frequency depends on the kisspeptin analogue used.

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Research Protocols & Common Usage

Doses used in research

Research studies have used 1–10mcg/kg intravenously
Subcutaneous community protocols commonly report 100–500mcg per injection

Administration routes studied

Intravenous (used in research settings)Subcutaneous injection (community protocols)

Typical protocol duration

Research protocols have used both acute doses and multi-week protocols. Community use varies significantly.

Common stacking protocols

Kisspeptin is typically used standalone for hormone axis support
Should not be combined with exogenous testosterone or anabolic steroids

Contraindications & combinations to avoid

Hormone-sensitive cancers (prostate, breast) — Kisspeptin stimulates LH/FSH and downstream sex hormone production
Exogenous testosterone or anabolic steroids — directly counteracts the intended mechanism
Active fertility treatments — consult a reproductive endocrinologist before use

Dosing information reflects doses used in published research and commonly reported community protocols only. This is not a personal recommendation. These compounds are not FDA-approved for human use in the contexts described. Consult a qualified healthcare provider before starting any protocol.

Considering stacking?

See the stacking guide for common combinations with Kisspeptin and what to avoid.

Stacking guide

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Community Reviews

Reviews reflect individual user experiences with research compounds and are not medical advice. Results vary. These compounds are not FDA approved for human use. Peptelligent does not verify reported experiences.