KPV
KPV (Lys-Pro-Val)
A tripeptide fragment of alpha-MSH with potent anti-inflammatory effects. Researched for gut disease, wound healing, and skin inflammation.
KPV is not approved by the FDA for human use. It is sold strictly for research purposes only and is not intended for human consumption, diagnosis, treatment, or prevention of any disease or condition. Purchase and use is entirely at your own risk.
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View at Ascension Peptides →What it is
KPV is a tripeptide consisting of three amino acids: lysine, proline, and valine. It represents the C-terminal sequence of alpha-MSH (alpha-melanocyte-stimulating hormone), itself derived from POMC (proopiomelanocortin).
What makes KPV unusual among peptides is its oral bioavailability — the small three-amino-acid structure is relatively stable in the GI tract, making oral administration meaningful for gut-specific conditions. It binds to the MC1R receptor and also exerts anti-inflammatory effects through non-receptor mechanisms involving NF-κB pathway inhibition.
What research shows
- Significant reduction in gut inflammation markers in animal models of IBD and colitis
- Accelerated wound closure and reduced inflammatory signaling in skin wound healing models
- Inhibition of NF-κB, a central driver of inflammatory gene expression
- Anti-inflammatory effects in intestinal epithelial cells through MC1R binding
- Potential benefit in skin inflammatory conditions including atopic dermatitis in early research
What remains unknown
- Long-term safety in humans — no extended human trials exist
- Optimal dose and route for different indications in humans
- Whether gut results in animals translate to human IBD or Crohn's disease
- Systemic bioavailability when dosed orally — gut-specific effects appear more reliable than systemic
Administration basics
Common use cases
Gut inflammation, IBD support, wound healing, skin conditions. Often used alongside BPC-157 for combined gut healing.
Half-life
Very short in plasma — minutes to a few hours. Gut stability appears relatively better when dosed orally.
Administration
Oral (capsule or solution for gut-specific effects), subcutaneous injection (for systemic anti-inflammatory use), topical (compounded for skin conditions).
Source this compound
Looking for KPV?
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View at Ascension PeptidesResearch Protocols & Common Usage
Doses used in research
- Animal studies used varying doses depending on route and indication — no direct human equivalent established
- Subcutaneous protocols in the community commonly report 0.5–1mg per injection
- Oral dosing for gut effects commonly reported at 2–5mg, though human bioavailability data is limited
- Topical: concentration varies by compounded formulation
Administration routes studied
Typical protocol duration
Typically 4–8 weeks in community protocols. Ongoing use reported for chronic inflammatory conditions.
Common stacking protocols
- KPV + BPC-157 + TB-500 + GHK-Cu (The KLOW Stack) — KPV completes this stack by adding anti-inflammatory control via MC1R and NF-κB inhibition to the GLOW foundation
- KPV + BPC-157 — frequently combined for gut healing; considered complementary anti-inflammatory mechanisms
- KPV + GHK-Cu — combined for wound healing and skin repair protocols
- KPV + LL-37 — combined in some gut and immune protocols for broad antimicrobial and anti-inflammatory coverage
Contraindications & combinations to avoid
- Human safety data is extremely limited — no long-term human trial data exists
- Autoimmune conditions — effects on immune modulation are not fully characterized; use with caution
- Pregnancy and breastfeeding — no safety data available
- Active infection — anti-inflammatory effects could theoretically blunt immune response to pathogens
Dosing information reflects doses used in published research and commonly reported community protocols only. This is not a personal recommendation. These compounds are not FDA-approved for human use in the contexts described. Consult a qualified healthcare provider before starting any protocol.
Considering stacking?
See the stacking guide for common combinations with KPV and what to avoid.
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Community Reviews
Reviews reflect individual user experiences with research compounds and are not medical advice. Results vary. These compounds are not FDA approved for human use. Peptelligent does not verify reported experiences.
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