Thymosin Alpha-1
Thymosin Alpha-1 (Tα1)
A 28-amino acid peptide derived from the thymus that modulates immune function, with clinical use in several countries for viral infections and cancer.
Thymosin Alpha-1 is not FDA-approved for human use in the United States. It has regulatory approval in some countries including Italy and China for antiviral and immune-related indications. In the US it is sold strictly for research purposes only and is not intended for human consumption.
Sourcing for research purposes?
View at Ascension Peptides →What it is
Thymosin Alpha-1 is a naturally occurring 28-amino acid peptide originally isolated from thymic tissue. It is a component of Thymosin Fraction 5, a thymus extract studied for its immune-modulating properties since the 1970s.
Unlike most peptides on this platform, Thymosin Alpha-1 (sold as Zadaxin) has regulatory approval in over 35 countries — primarily in Asia and Eastern Europe — for use in hepatitis B, hepatitis C, and as an adjunct in cancer treatment. It has completed numerous human clinical trials.
What research shows
- Enhances T-cell maturation and function in immunocompromised patients
- Antiviral activity demonstrated in hepatitis B and C trials
- Adjunct cancer treatment — improves immune response alongside standard therapies
- Potential benefit in sepsis — large trials conducted in China
- Anti-inflammatory effects through dendritic cell and regulatory T-cell modulation
What remains unknown
- Optimal dosing protocols for healthy individuals (most data is in disease populations)
- Long-term safety in chronic use outside of approved indications
- Benefit in healthy immune systems vs. immunocompromised populations
Administration basics
Common use cases
Immune support, recovery from illness, adjunct in cancer protocols, antiviral support.
Half-life
~2 hours.
Administration
Subcutaneous injection. Standard research dose typically twice weekly.
Source this compound
Looking for Thymosin Alpha-1?
Ascension Peptides is a third-party research compound vendor. We link to them as an affiliate — if you purchase through our link we may earn a commission at no cost to you. All compounds are sold for research purposes only and are not intended for human use.
View at Ascension PeptidesResearch Protocols & Common Usage
Doses used in research
- Clinical trials (Zadaxin) have used 1.6mg subcutaneously twice weekly
- Community immune support protocols typically follow the 1.6mg twice-weekly clinical standard
Administration routes studied
Typical protocol duration
Hepatitis trials used 6-month protocols. Community immune support protocols commonly report 4–12 weeks.
Common stacking protocols
- Thymosin Alpha-1 + BPC-157 — combined in protocols targeting healing with immune support
- Thymosin Alpha-1 + LL-37 — combined for broad innate and adaptive immune support
- Thymosin Alpha-1 + Thymalin — used in Russian peptide bioregulator protocols targeting immune restoration
Contraindications & combinations to avoid
- Autoimmune conditions — Thymosin Alpha-1 stimulates immune activity; this could potentially exacerbate autoimmune diseases
- Organ transplant recipients on immunosuppressants — immune stimulation directly counteracts immunosuppressive therapy
Dosing information reflects doses used in published research and commonly reported community protocols only. This is not a personal recommendation. These compounds are not FDA-approved for human use in the contexts described. Consult a qualified healthcare provider before starting any protocol.
Considering stacking?
See the stacking guide for common combinations with Thymosin Alpha-1 and what to avoid.
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Reviews reflect individual user experiences with research compounds and are not medical advice. Results vary. These compounds are not FDA approved for human use. Peptelligent does not verify reported experiences.
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