Nootropic

VIP

VIP (Vasoactive Intestinal Peptide)

A 28-amino acid neuropeptide with potent anti-inflammatory, immune-modulating, and bronchodilatory properties. Used in CIRS protocols.

VIP is not approved by the FDA for human use. It is sold strictly for research purposes only and is not intended for human consumption, diagnosis, treatment, or prevention of any disease or condition. Purchase and use is entirely at your own risk.

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What it is

Vasoactive Intestinal Peptide (VIP) is a naturally occurring 28-amino acid neuropeptide found throughout the central and peripheral nervous systems, gut, and lungs. It was first isolated from pig intestine in 1970.

Its biological roles span immune regulation, vasodilation, bronchodilation, and circadian rhythm entrainment. In clinical practice, it has gained significant attention through Dr. Ritchie Shoemaker's CIRS (Chronic Inflammatory Response Syndrome) protocols, where intranasal VIP is used as a late-stage treatment for biotoxin illness.

What research shows

Anti-inflammatory — suppresses pro-inflammatory cytokines (TNF-α, IL-6, IL-12)
Bronchodilation — research in pulmonary arterial hypertension and asthma
Circadian rhythm regulation and sleep quality improvement
Immune modulation — promotes regulatory T-cell activity
CIRS protocol data showing TGF-beta and other biomarker normalization

What remains unknown

Long-term safety profile with chronic intranasal use
Efficacy outside of CIRS/biotoxin illness context in controlled trials
Optimal dosing across different indications
Extent to which intranasal delivery achieves meaningful CNS concentrations

Administration basics

Common use cases

CIRS (biotoxin illness) treatment, immune modulation, anti-inflammatory protocols, pulmonary conditions.

Half-life

~1–2 minutes in plasma. CNS effects via intranasal are longer-acting.

Administration

Intranasal is primary route in CIRS protocols. IV use in pulmonary research.

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Research Protocols & Common Usage

Doses used in research

Research has used 50–100mcg intranasally
CIRS community protocols commonly report 50mcg intranasally twice daily

Administration routes studied

Intranasal (most practical for community use)Intravenous (used in research and some clinical protocols)

Typical protocol duration

CIRS protocols have used VIP over several weeks to months. Research protocols vary by indication.

Common stacking protocols

VIP is typically used as part of comprehensive CIRS treatment protocols rather than general peptide stacking

Contraindications & combinations to avoid

Hypotension — VIP is a potent vasodilator; should not be combined with blood pressure lowering medications without monitoring
VIP should ideally be used only under physician supervision for CIRS protocols

Dosing information reflects doses used in published research and commonly reported community protocols only. This is not a personal recommendation. These compounds are not FDA-approved for human use in the contexts described. Consult a qualified healthcare provider before starting any protocol.

Considering stacking?

See the stacking guide for common combinations with VIP and what to avoid.

Stacking guide

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Community Reviews

Reviews reflect individual user experiences with research compounds and are not medical advice. Results vary. These compounds are not FDA approved for human use. Peptelligent does not verify reported experiences.

VIP